Perspectives on Computer Aided Drug Discovery

The drug development and discovery process are challenging, take 15 to 20 years, require approximately 1.5-2 billion dollars, from the critical selection of target molecule post-clinical market application. Several computational design methods identify optimize biologically lead compounds. Given complexity cost in recent computer-assisted (CADD) has spread over a broad spectrum. CADD support molecules, optimization small analysis, processes faster less costly. These can be classified into structure-based (SBDD) ligand-based (LBDD). SBDD begins by focusing on knowledge three-dimensional structure biological target. Finally, this review article provides an overview details, purposes, uses developing drugs, general workflows, tools used, limitations, future methods, including LBDD that have become integral part pharmaceutical companies academic research.